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Vaccine Manufacturing Facility
MECART was tasked with creating 14,000 square feet of Class B, C, and D clean rooms that adhered to GMP standards for vaccine development. The cleanrooms were delivered in less than 5 months, and the entire facility was completed in less than 10 months!
Location:
Canada
Industry:
Vaccine Production / Biomanufacturing
Application:
Biologics and Vaccine Manufacturing
Size:
14 000 sqft
Cleanroom Class:
GMP Grades (Grade B, C & D)
Many vaccine manufacturing facilities are being built worldwide to be fully prepared to address the next pandemic or support global vaccination efforts.
The pandemic has demonstrated the shortcomings of not having access to locally manufactured vaccines, which creates a dependence on foreign vaccines, which may be challenging to obtain for financial reasons or political advantage.
This 14,000-square-foot clean room in a vaccine manufacturing plant was delivered in less than 5 months. The entire biomanufacturing facility was completed only 10 months after breaking ground.
The layout consists of a media preparation room, a packaging room, two subculture rooms, a buffer preparation room, personnel airlocks (PAL), and material airlocks (MAL). The vaccine factory’s clean rooms comply with good manufacturing practices (cGMP).
Modular vs. Traditional Cleanrooms: A Faster Solution
Modular construction often occurs in sync with site and foundation work, allowing projects to be completed 30 to 50 percent faster than traditional construction. In other words, the wall and ceiling modular panels are manufactured off-site simultaneously as the conventional (stick-built) construction breaks ground, saving a lot of time in the process.
Thanks to collaborative work between Mecart and general contractors, it has been possible to deliver high-end GMP cleanrooms in record time for the brand-new vaccine manufacturing facility.
As vaccination needs in Canada intensified during the pandemic, the demand for vaccine manufacturing facilities rose rapidly too. It became an urgent matter to provide vaccines to Canadians.
Our client came to us with a daunting challenge: to provide 14,000 square feet of clean room space for their vaccine manufacturing facility within a few months.
Modular construction is known to be faster than traditional construction, but still, building and delivering 14,000 square feet of custom cleanroom in less than 5 months still represents a significant challenge.
Here are a few examples of the advantages of choosing a modular cleanroom manufacturer for your vaccine plant cleanrooms:
- Modular walls can be removed to accommodate new, larger equipment as needed (2000L bioreactors, for example)
- Design flexibility (mobility, expandability, etc.)
- Cleaner installation on-site
- Faster installation on-site (can be fully prefab off-site or assembled directly on-site)
- Higher and consistent quality, since production is done under ISO 9001 quality management system at Mecart’s plant
Modular was the better choice for a faster completion. It was 100% exactly what we expected! MECART really delivered the product that was intended.
2 Levels of Ceiling Height to Accommodate Bioreactors
Bioreactors are essential for developing and manufacturing vaccines, from small laboratory fermenters (1L to 50L capacity) to 2000-liter plant scale bioreactors.
This vaccine manufacturing facility contains different sized bioreactors for scaling up vaccine production for future pandemics. The various dimensions of their bioreactors came with the need for different ceiling heights for the 2000L bioreactors.
Air treatment and air changes are very energy consuming to maintain the cleanliness levels necessary for vaccine production. To save the customer energy and lower operation costs, Mecart came up with a solution.
Rather than having the entire clean room with 14-foot-high ceilings, 2 ceiling height levels were incorporated into the room to decrease the total amount of air to be cleaned. As seen in the picture, one of the clean rooms has a ceiling with 2 different heights to allow the 2000L bioreactors to fit without obstruction while reducing the energy bill. Here, we can see a 14-foot-high ceiling next to a 9’6’’ ceiling.
There are 4 different cleanroom ceiling heights (14 ft., 12 ft., 10 ft., and 9’6’’ ft.) in this vaccine manufacturing facility for numerous different equipment sizes, operational reasons, and cost savings.
GMP Design Features
Vaccine manufacturing facilities and vaccine production need to comply with GMP guidelines to assure drug safety for the end-user. In the picture above, we can see multiple flush design features used for this vaccine manufacturing facility.
- Fire Sprinklers: recessed in the ceiling and come out only in case of fire
- Air Returns
- HEPA Filters
- Flush Windows
- Flush Lighting
- Cleanroom Coving: Coving is a piece of material that is used to cover the seam between two surfaces, such as the intersection of two walls or the connection between a wall and the ceiling or floor
These flush finish features make it easier to clean the vaccine manufacturing facility and its cleanroom environments, making it easier to remain GMP compliant.
Biologics and Vaccine Production
Vaccine production requires rigorous conditions to be manufactured. Vaccine manufacturing facilities must have cleanroom environments that meet strict GMP standards. You can visit our page Vaccine Manufacturing Facility Design to learn more on this matter.
Mecart was approached by this manufacturer of vaccines and biological products to obtain cleanrooms that would meet GMP standards
With a tight schedule, this client was looking to do business with a cleanroom manufacturer with a proven track record of delivering GMP cleanrooms, and that would have the capabilities to provide a fast-track project.
Mecart can meet both GMP requirements and short lead times with its modular cleanroom solutions. Have a similar project? Contact us !
To learn more about GMP compliant cleanroom, here are a few related articles that will help you understand better:
- https://www.mecart-cleanrooms.com/learning-center/gmp-facility-understanding-grade-a-grade-b-grade-c-and-d/
- https://www.mecart-cleanrooms.com/learning-center/designing-a-cgmp-cleanroom-for-cell-and-gene-therapy-cgt/
- https://www.mecart-cleanrooms.com/applications/vaccine-manufacturing-facility-design/
Mecart’s cleanroom design and manufacturing expertise make us the right partner for fast and custom vaccine manufacturing facility buildings.